Is inheritable genetic modification the new dividing line in gene therapy? The editors of this searching investigation, representing clinical medicine, public health and biomedical ethics, have established a distinguished team of scientists and scholars to address the issues from the perspectives of biological and social science, law and ethics, including an intriguing Foreword from Peter Singer. Their purpose is to consider how society might deal with the ethical concerns raised by inheritable genetic modification, and to re-examine prevailing views about whether (...) these procedures will ever be ethically and socially justifiable. The book also provides background to define the field, and discusses the biological and technological potential for inheritable genetic modification, its limitations, and its connection with gene therapy, cloning, and other reproductive interventions. For scientists, bioethicists, clinicians, counsellors and public commentators, this is an essential contribution to one of the critical debates in current genetics. (shrink)

Evolutionary theories of schizophrenia must account for the maintenance of putative alleles in past and present populations despite reduced fitness among the affected. Such models must also account for extant intersex and population-level variability in the expression of schizophrenia. We argue that genetic balanced-polymorphism hypotheses remain the most robust in terms of modeling and testing these processes in populations.

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

Many believe that the ethical problems of donation after cardiocirculatory death (DCD) have been "worked out" and that it is unclear why DCD should be resisted. In this paper we will argue that DCD donors may not yet be dead, and therefore that organ donation during DCD may violate the dead donor rule. We first present a description of the process of DCD and the standard ethical rationale for the practice. We then present our concerns with DCD, including the following: (...) irreversibility of absent circulation has not occurred and the many attempts to claim it has have all failed; conflicts of interest at all steps in the DCD process, including the decision to withdraw life support before DCD, are simply unavoidable; potentially harmful premortem interventions to preserve organ utility are not justifiable, even with the help of the principle of double effect; claims that DCD conforms with the intent of the law and current accepted medical standards are misleading and inaccurate; and consensus statements by respected medical groups do not change these arguments due to their low quality including being plagued by conflict of interest. Moreover, some arguments in favor of DCD, while likely true, are "straw-man arguments," such as the great benefit of organ donation. The truth is that honesty and trustworthiness require that we face these problems instead of avoiding them. We believe that DCD is not ethically allowable because it abandons the dead donor rule, has unavoidable conflicts of interests, and implements premortem interventions which can hasten death. These important points have not been, but need to be fully disclosed to the public and incorporated into fully informed consent. These are tall orders, and require open public debate. Until this debate occurs, we call for a moratorium on the practice of DCD. (shrink)

"Contemporary Mind - Some Modern Answers" is a fantastic collection of essays by English science writer John W. Sullivan. They deal with a range of subjects, ranging from mysticism and immortality to the relationship between science and art. John William Navin Sullivan (1886 - 1937) was a literary journalist and popular science writer most famous for his study of Beethoven. He is also responsible for having written some of the earliest non-technical accounts of Einstein's General Theory (...) of Relativity, and he was acquainted with many important writers in London in the 1920s, including John Middleton Murry, Aldous Huxley, Wyndham Lewis, Aleister Crowley and T. S. Eliot. Other notable works by this author include "Aspects of Science" (1923), "Aspects of Science: Second Series" (1926), and An Outline of Modern Knowledge (1931). Contents include: "The Balanced Life," "The Problem of Suffering," "The Necessity of Mysticism," "Human Immortality," "A Dissertation on Beethoven," "The Scientific Outlook," "A Dissertation on Maxwell," "New Principles," "A Dissertation on Newton," "Science and Art," "Mathematics and Culture," "Sir Josiah Stamp," "Mr. Aldous Huxley," etc. Many vintage books such as this are increasingly scarce and expensive. It is with this in mind that we are republishing this volume now in an affordable, modern, high-quality edition complete with the original text and artwork. (shrink)

This brief introduction to a special issue of Disputatio succinctly summarizes John Perry’s pluri-propositionalist reflexive framework and notes some potential applications to varieties of context-sensitivity.

One of the more striking developments in contemporary philosophic discussions about morality has been the rise of anti-theory — the rejection of moral theories as ‘unnecessary, undesirable, and/or impossible’. Among those associated with this view have been Bernard Williams, John McDowell, Edmund Pincoffs and James Wallace.

This chapter addresses the issues that motivate representationalist accounts, and it describes the different versions of representationalism as responses to these issues. It argues that the representationalist views do not adequately respond to the epistemological problems that motivate them and that they engender some ontological problems. The chapter presents an alternative ‘presentationalist’ account that preserves the straightforward sense of the mind's openness to the world. While representationalism and presentationalism agree that the relation between mental events or states is direct but (...) mediated, they radically differ in their views of the nature of the mediation involved in the mind's intentional directedness to the world. This difference and the preferability of the presentationalist account are explored. (shrink)

Here, in a single volume, is a comprehensive and definitive account of pragmatism and classical American philosophy. Pragmatism and Classical American Philosophy, now revised and expanded in this second edition, presents the essential writings of the major philosophers of this tradition: Charles S. Peirce, William James, Josiah Royce, George Santayana, John Dewey, and George Herbert Mead. Illuminating introductory essays, written especially for this volume by distinguished scholars of American philosophy, provide biographical and cultural context as well as original critical (...) and interpretive perspectives. This edition also includes all new selections and interpretive essays that situate pragmatism and classical American philosophy in a wider American philosphical context, including: Ralph Waldo Emerson and transcendentalism; Jane Addams, feminism, and writings of American women; Borden Parker Bowne, personalism, and idealism; Alain Locke and Afro-American thought; and John Herman Randall, Jr., nationalism and realism. Up-to-date suggestions for further reading will benefit both introductory and advanced readers. This American intellectual tradition speaks insightfully, creatively, and critically to our contemporary global society and its pressing problems. In unmatched quality and quantity, Pragmatism and Classical American Philosophy provides the resources necessary to understand and act on these insights. (shrink)

Building Better Health Care Leadership for Canada explains the development and implementation of the Executive Training in Research Application program. Managed and funded by the Canadian Health Services Research Foundation in partnership with the Canadian Medical Association, the Canadian Nursing Association, and the Canadian College of Health Care executives, EXTRA is a two-year national fellowship program that uses the principles of adult learning theory as well as practical projects to educate senior health care leaders in making more consistent use of (...) research evidence in their management roles. Fellows apply the theory learned in residency sessions and educational activities to projects within their home organizations. The authors identify the imperative for better use of evidence, outline the core elements of the curriculum, and capture the real-world experience of regional leaders and fellows involved in making specific changes informed by research-based evidence within their organization. Contributors include Jean-Louis Denis, Terrence Sullivan, Owen Adams, Malcolm Anderson, Lynda Atack, Robert Bell, Sam G Campbell, Sylvie Cantin, Ward Flemons, Dorothy Forbes, J. Sonja Glass, Paula Goering, Karen Golden-Biddle, Jeffrey S. Hoch, Paul Lamarche, Ann Langley, John N. Lavis, Jonathan Lomas, Margo Orchard, Raynald Pineault, Brian D. Postl, Christine Power, Trish Reay, Jean Rochon, Denis A. Roy, Andrea Seymour, Samuel B. Sheps, Micheline Ste-Marie, Nina Stipich, David Streiner, Carl Taillon, and Muriah Umoquit. (shrink)

The adolescing self -- Imaging and fettered imaging -- Characteristics of the superego God -- Adolescing religion and formal religion -- Images of the superego God -- The adult self -- Unfettered imaging and religious experiencing -- Characteristics of the living God -- Adult religion and integral spirituality -- Images of the living God -- Transformation and why it gets so little attention -- What hinders transformation -- What facilitates transformation -- Images of transformation.

This volume is devoted entirely to exploring the role of animals in the thought of Immanuel Kant. Leading scholars address questions regarding the possibility of objective representation and intentionality in animals, the role of animals in Kant's scientific picture of nature, the status of our moral responsibilities to animals' welfare, and more.

This volume contains papers originally presented to the Boston Area Colloquium in Ancient Philosophy during 2005-6. Of the seven colloquia, two deal with topics in Neoplatonism, four are dedicated to Aristotle’s ethics and metaphysics, and one to Plato’s Republic.

In the last two decades, interest in narrative conceptions of identity has grown exponentially, though there is little agreement about what a "life-narrative" might be. In connecting Kierkegaard with virtue ethics, several scholars have recently argued that narrative models of selves and MacIntyre's concept of the unity of a life help make sense of Kierkegaard's existential stages and, in particular, explain the transition from "aesthetic" to "ethical" modes of life. But others have recently raised difficult questions both for these readings (...) of Kierkegaard and for narrative accounts of identity that draw on the work of MacIntyre in general. While some of these objections concern a strong kind of unity or "wholeheartedness" among an agent's long-term goals or cares, the fundamental objection raised by critics is that personal identity cannot _be_ a narrative, since stories are artifacts made by persons. In this book, Davenport defends the narrative approach to practical identity and autonomy in general, and to Kierkegaard's stages in particular. (shrink)

With one exception, the papers in this volume were originally presented to the Boston Area Colloquium in Ancient Philosophy during 2006-7. Five colloquia deal directly with Plato, while another discusses Heidegger's interpretation of Plato. Two colloquia deal with the Epicurean notion of preconception and with the Stoic conception of the good.

This volume contains papers and commentaries originally presented to the Boston Area Colloquium in Ancient Philosophy during the 2004-5 academic year. Of the seven colloquia in the volume, two deal with Plato while the rest are dedicated to Aristotle.

This latest BACAP Proceedings covers three key areas in ancient philosophy, ethics, method and physics. Under ethics, there are three papers on Socratic piety, Aristotelian friendship, and Augustinian-Platonic virtue. Under method, Socratic elenchos, Socratic maieutic, and Aristotelian aporematic inquiry. Under physics, life in Plato and mo.

This volume represents some of the activities of the Boston Area Colloquium in Ancient Philosophy from the academic year 1997-98. It contains nine colloquia that were hosted by eight different colleges and universities in the greater Boston area. Discussions of the works of Plato dominate this volume, with six of the nine colloquia based on Platonic texts. Appropriately, the colloquia begin with an analysis of division in the ancient atomists. Later, a study of truth in Aristotle gives a counterpoint to (...) the Platonic interplay of drama and pedagogy or logic and rhetoric examined in papers about the "Theaetetus" and "Symposium". A presentation of Proclus’s account of evil revisits some of the issues of sophistry and morality discussed in relation to Plato’s "Republic" and "Euthydemus". Finally, the remaining Platonic papers are in a way not about Plato at all, but about Socrates and Xanthippe, supplementing Platonic dialogues with Xenophon and others. Underneath these discussions of ancient texts current modes of philosophy run along, providing a score of alternative interpretative schemes._ This publication has also been published in paperback, please click here_ for details. (shrink)

This latest volume of _BACAP Proceedings_ contains some innovative research by international scholars on Plato, Aristotle, and Sophocles. It covers such themes as Plato on the philosopher ruler, and Aristotle on essence and necessity in science._ This publication has also been published in hardback, please click here_ for details.

Most of the colloquia explore important topics such as the notion of self in Plato and the relationship between sense and knowledge in Aristotle. In addition, two colloquia discuss the origins of Pyrrhonic scepticism and the themes of Seneca’s _Natural Questions_._ This publication has also been published in hardback, please click here_ for details.

This latest volume of BACAP Proceedings contains some innovative research by international scholars on Plato and Aristotle. It covers such themes as Plato on recollection and on justice, along with Aristotle on Nous and on law._ This publication has also been published in hardback, please click here_ for details.

This volume of BACAP Proceedings contains recent research by international scholars on Empedocles, Plato, Aristotle, Plotinus and some Hellenistic philosophers. It covers such topics as Epicurean methods of managing mental pain, moral nostalgia in Plato' s Republic, and empty terms in Aristotelian logic._ This publication has also been published in paperback, please click here_ for details.

This volume of the Proceedings continues the success of the Colloquium in providing a venue where a wide range of classical themes and figures is examined from the multiple perspectives of the current philosophical scene. This diversity gives the Proceedings a unique appeal to all those, philosophers and classicists, interested in the long tradition of ancient thought in both Greek and Latin._ This publication has also been published in paperback, please click here_ for details.

This volume of the Proceedings continues the success of the Colloquium in providing a venue where a wide range of classical themes and figures is examined from the multiple perspectives of the current philosophical scene. This diversity gives the Proceedings a unique appeal to all those, philosophers and classicists, interested in the long tradition of ancient thought in both Greek and Latin._ This publication is also available in hardback, please click here_ for details._ Also published as issue 1 of Volume (...) 20 of Brill Academic Publisher's journal _Boston Area Colloquium in Ancient Philosophy_. For more details on this journal, please click here_. (shrink)

This book examines Aristotle's critical reaction to the mathematical cosmology of Plato's Academy, and traces the aporetic method by which he developed his own ...

The 1990s saw a revival of interest in Kierkegaard's thought, affecting the fields of theology, social theory, and literary and cultural criticism. The resulting discussions have done much to discredit the earlier misreadings of Kierkegaard's works.

Towards the conclusion of the First Section of the Groundwork of the Metaphysics of Morals, Kant describes a process whereby a subject can undergo a kind of moral corruption. This process, which he calls a “natural dialectic”, can cause one to undermine one’s own or¬dinary grasp of the demands of morality. Kant also claims that this natural dialectic is the basis of the need for moral philosophy itself, since first-order moral reasoning is insufficient to protect against it. I show that (...) this passage is closely related to another in the First Section, one where Kant warns against the threat of “misology”, or the hatred of reason. I argue that both these passages must be read as engaging with specific claims from Rousseau’s writings. Uncovering the historical context and rhetorical function of Kant’s account of moral self-deception can re-orient the reader to his ambitions for the Groundwork itself. (shrink)

In this book, the authors present current research in the study of the philosophy of the mind. Topics discussed in this compilation include the concepts of hope and belief; how consciousness builds the subject through relating and human behaviour; analysing the neurophysiological mechanism of qigong on the mind and brain activity; the conscious and unconscious mind and implications for society, religion, and disease; how the mind is shaped by culture; and the power of computational mathematics to explore some of the (...) universal ways by which each human mind builds its image of the world. (shrink)

Pragmatism, Postmodernism and the Future of Philosophy is a vigorous and dynamic confrontation with the task and temperament of philosophy today. In this energetic and far-reaching new book, Stuhr draws persuasively on the resources of the pragmatist tradition of James and Dewey, and critically engages the work of Continental philosophers like Adorno, Foucault, and Deleuze, to explore fundamental questions of how we might think and live differently in the future. Along the way, the book addresses important issues in public policy, (...) university administration, spirituality, and the notion of community and its meaning in a global world of difference. This book is essential reading for anyone concerned with the future of philosophy, and the ways in which philosophical thinking can help us live better, more fulfilling lives. (shrink)